MAPT-AS1

Across TCGA pan-cancer cohorts, MAPT-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MAPT-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAPT-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAPT-AS1 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

KIRC, BRCA, and COAD are the cancer types where MAPT-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAPT-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.317	.001	7	view →
BRCA	All	All	+0.499	<.001	6	view →
COAD	All	All	−0.038	<.001	6	view →
HNSC	All	All	−0.028	.006	6	view →
KICH	All	All	−0.267	.010	4	view →
STAD	All	All	−0.031	.025	4	view →
ESCA	All	II,III,IV	−0.084	.003	2	view →
LUSC	All	All	+0.015	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MAPT-AS1–KIRC

Open the KIRC breakdown →