MAPRE2

Across TCGA patient cohorts, MAPRE2 mutation is significantly associated with the RNA expression of many other genes, with 1,057 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPRE2-associated genes across cancer lineages are LCN1P2, RNU6-1086P, and RPL21P112. Each is linked with MAPRE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPRE2-to-partner and partner-to-MAPRE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCN1P2 grouped by MAPRE2-low versus MAPRE2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPRE2→partner) and Y-score (partner→MAPRE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LCN1P2 →	+0.195	+4.707	.003	<.001	3	2
HNSC	RNU6-1086P →	+0.416	+6.468	<.001	.001	3	2
LUSC	RPL21P112 →	+0.156	+3.578	<.001	.004	3	2
LUSC	RN7SL189P →	+0.110	+3.832	.008	.004	3	2
LUSC	MIR3115 →	+0.515	+4.196	<.001	.001	3	2
LUSC	MIR6803 →	+0.218	+4.733	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,057 associations by consensus.

LCN1P2 by MAPRE2 expression — COAD

Explore this box plot interactively →