MAPRE1

Across TCGA patient cohorts, MAPRE1 mutation is significantly associated with the RNA expression of many other genes, with 664 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPRE1-associated genes across cancer lineages are FGFR3P1, MIR6803, and RNA5SP146. Each is linked with MAPRE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPRE1-to-partner and partner-to-MAPRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGFR3P1 grouped by MAPRE1-low versus MAPRE1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPRE1→partner) and Y-score (partner→MAPRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FGFR3P1 →	+0.106	+5.015	<.001	.009	3	2
UCEC	MIR6803 →	+0.161	+4.571	<.001	.002	3	2
UCEC	RNA5SP146 →	+0.371	+2.261	<.001	.007	3	2
UCEC	SLC35C2P1 →	+0.121	+2.103	.003	.002	3	2
UCEC	PINCR →	+0.184	+2.382	.001	<.001	3	2
UCEC	IKBKE →	-0.820	-3.692	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 664 associations by consensus.

FGFR3P1 by MAPRE1 expression — HNSC

Explore this box plot interactively →