MAPKAPK5

Across TCGA cell cohorts, MAPKAPK5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,186 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAPKAPK5-associated GO terms across cancer lineages are mRNA alternative polyadenylation, Transcription elongation-coupled chromatin remodeling, and Extracellular matrix organization. Each is linked with MAPKAPK5 in more than 13 cancer types. Because this analysis shows association rather than direction, both MAPKAPK5-to-partner and partner-to-MAPKAPK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by MAPKAPK5-low versus MAPKAPK5-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAPK5→partner) and Y-score (partner→MAPKAPK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.070	+0.461	.005	.008	2	14
BONE	Transcription elongation-coupled chromatin remodeling →	+0.116	+0.597	<.001	<.001	3	13
SOFT_TISSUE	Extracellular matrix organization →	-0.164	-0.688	<.001	<.001	3	13
SOFT_TISSUE	External encapsulating structure organization →	-0.166	-0.688	<.001	<.001	3	13
BONE	Negative regulation of transcription by RNA polymerase I →	+0.118	+0.632	<.001	<.001	3	13
BONE	Regulation of DNA repair →	+0.060	+0.589	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,186 associations by consensus.

mRNA alternative polyadenylation by MAPKAPK5 expression — LARGE_INTESTINE

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