MAPKAPK5

Across TCGA cell cohorts, MAPKAPK5 mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPKAPK5-associated genes across cancer lineages are Mirin, PAK_5339, and Zibotentan. Each is linked with MAPKAPK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPKAPK5-to-partner and partner-to-MAPKAPK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by MAPKAPK5-low versus MAPKAPK5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAPK5→partner) and Y-score (partner→MAPKAPK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.407	+2.646	.031	.047	3	1
LARGE_INTESTINE	PAK_5339 →	+0.325	+2.649	.029	.046	3	1
LARGE_INTESTINE	Zibotentan →	+0.211	+2.652	.038	.045	3	1
LARGE_INTESTINE	KIN001-236 →	+0.337	+2.652	.018	.045	3	1
LARGE_INTESTINE	WYE-125132 →	+0.526	+2.652	.040	.045	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.486	+2.652	.040	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Mirin by MAPKAPK5 expression — LARGE_INTESTINE

Explore this box plot interactively →