MAPKAPK5-AS1

Across TCGA pan-cancer cohorts, MAPKAPK5-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAPKAPK5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAPKAPK5-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAPKAPK5-AS1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where MAPKAPK5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAPKAPK5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.504	<.001	12	view →
KIRP	All	II,III,IV	+0.709	<.001	11	view →
HNSC	Male	III,IV	+1.054	<.001	10	view →
BLCA	All	All	+0.715	<.001	10	view →
LIHC	Female	II,III,IV	+1.485	<.001	9	view →
STAD	All	II,III,IV	+0.708	<.001	6	view →
COAD	All	All	+0.442	<.001	6	view →
CHOL	All	All	+2.255	<.001	5	view →
ESCA	All	All	+0.806	<.001	4	view →
LUAD	Female	II,III,IV	−0.509	.002	3	view →
READ	Female	All	+0.871	.005	2	view →
LUSC	All	All	+0.230	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAPKAPK5-AS1–KIRC

Open the KIRC breakdown →