MAPKAPK3

Across TCGA patient cohorts, MAPKAPK3 mutation is significantly associated with the RNA expression of many other genes, with 151 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPKAPK3-associated genes across cancer lineages are IFNWP9, MIR196A2, and WHAMM. Each is linked with MAPKAPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPKAPK3-to-partner and partner-to-MAPKAPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNWP9 grouped by MAPKAPK3-low versus MAPKAPK3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAPK3→partner) and Y-score (partner→MAPKAPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IFNWP9 →	+0.139	+4.198	<.001	.003	3	2
SKCM	MIR196A2 →	+0.396	+3.632	<.001	.001	3	2
UCEC	WHAMM →	+0.687	+3.234	<.001	.009	3	1
BLCA	RNU6-832P →	+0.353	+7.640	<.001	.009	3	1
BLCA	RNU6-639P →	+0.588	+7.640	<.001	.009	3	1
BLCA	RNU6-38P →	+0.908	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 151 associations by consensus.

IFNWP9 by MAPKAPK3 expression — LUAD

Explore this box plot interactively →