MAPK8IP3

Across TCGA patient cohorts, MAPK8IP3 mutation is significantly associated with the RNA expression of many other genes, with 3,811 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK8IP3-associated genes across cancer lineages are CIAO2B, CCDC92, and CHMP7. Each is linked with MAPK8IP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAPK8IP3-to-partner and partner-to-MAPK8IP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CIAO2B grouped by MAPK8IP3-low versus MAPK8IP3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8IP3→partner) and Y-score (partner→MAPK8IP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CIAO2B →	+0.337	+1.991	.002	.007	3	4
COAD	CCDC92 →	-0.509	-3.429	.001	.005	3	4
STAD	CHMP7 →	+0.610	+3.476	<.001	.002	3	4
STAD	VPS37A →	+0.599	+3.194	<.001	.009	3	4
STAD	VANGL2 →	-1.564	-3.459	<.001	.005	3	4
STAD	BNIP3L →	+0.730	+3.347	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,811 associations by consensus.

CIAO2B by MAPK8IP3 expression — SKCM

Explore this box plot interactively →