MAPK8IP3

Across TCGA pan-cancer cohorts, MAPK8IP3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MAPK8IP3 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MAPK8IP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAPK8IP3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

KIRC, UVM, and BLCA are the cancer types where MAPK8IP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.461	0.703	<.001	86	view →
UVM	DFS	Quartile	II,III,IV	0.274	0.682	.007	46	view →
BLCA	OS	Quartile	II,III,IV	0.646	0.406	.003	43	view →
SKCM	OS	Quartile	All	0.435	0.229	<.001	38	view →
HNSC	DFS	Quartile	IV	0.480	0.287	.005	33	view →
MESO	OS	Median	All	0.295	0.462	.011	29	view →
PRAD	DFS	Median	All	0.825	0.938	<.001	26	view →
COAD	DFS	Quartile	All	0.418	0.692	.013	24	view →
LIHC	DFS	Quartile	All	0.409	0.582	.002	21	view →
LUSC	DFS	Quartile	III,IV	0.295	0.839	.013	18	view →
PAAD	DFS	Tertile	All	0.571	0.397	.005	18	view →
KIRP	OS	Median	III,IV	0.159	0.732	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MAPK8IP3–KIRC (DFS)

Open the KIRC breakdown →