MAPK8IP3

Across TCGA patient cohorts, MAPK8IP3 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK8IP3-associated genes across cancer lineages are Lck, Notch1, and PRDX1. Each is linked with MAPK8IP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPK8IP3-to-partner and partner-to-MAPK8IP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by MAPK8IP3-low versus MAPK8IP3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8IP3→partner) and Y-score (partner→MAPK8IP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Lck →	+0.415	+2.195	.003	.034	3	3
UCEC	Notch1 →	+0.116	+1.530	.006	.004	3	3
UCEC	PRDX1 →	+0.128	+1.247	.039	.041	3	3
UCEC	Rad50 →	-0.244	-1.986	<.001	.008	3	3
UCEC	c-Kit →	-0.178	-2.102	.011	.016	3	3
CESC	ACC_pS79 →	+0.345	+3.000	.035	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Lck by MAPK8IP3 expression — COAD

Explore this box plot interactively →