MAPK8IP3

Across TCGA cell cohorts, MAPK8IP3 mutation is significantly associated with the RNA expression of many other genes, with 763 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK8IP3-associated genes across cancer lineages are OR56A1, TP53TG3C, and TP53TG3F. Each is linked with MAPK8IP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK8IP3-to-partner and partner-to-MAPK8IP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A1 grouped by MAPK8IP3-low versus MAPK8IP3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8IP3→partner) and Y-score (partner→MAPK8IP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR56A1 →	+0.006	+4.357	<.001	.004	3	2
CNS	TP53TG3C →	+1.054	+3.630	<.001	.006	3	2
CNS	TP53TG3F →	+0.840	+3.836	<.001	.003	3	2
LARGE_INTESTINE	FAM184A →	+1.035	+3.364	<.001	.002	3	2
LARGE_INTESTINE	CT45A3 →	+0.159	+2.479	.004	.002	3	2
LARGE_INTESTINE	PSMD5 →	+0.661	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 763 associations by consensus.

OR56A1 by MAPK8IP3 expression — CNS

Explore this box plot interactively →