MAPK8IP2

Across TCGA patient cohorts, MAPK8IP2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK8IP2-associated genes across cancer lineages are TIGAR, eEF2, and EGFR_pY1068. Each is linked with MAPK8IP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK8IP2-to-partner and partner-to-MAPK8IP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by MAPK8IP2-low versus MAPK8IP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8IP2→partner) and Y-score (partner→MAPK8IP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.224	+1.901	.001	.031	3	2
UCEC	eEF2 →	+0.640	+2.321	<.001	.033	3	1
UCEC	EGFR_pY1068 →	-0.320	-2.999	.006	.035	3	1
UCEC	GAPDH →	+0.672	+2.999	.007	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.249	-3.169	.001	.019	3	1
UCEC	p70-S6K_pT389 →	-0.183	-2.312	.039	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TIGAR by MAPK8IP2 expression — UCEC

Explore this box plot interactively →