MAPK8IP2

Across TCGA pan-cancer cohorts, MAPK8IP2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MAPK8IP2 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher MAPK8IP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAPK8IP2 expression acts as an unfavorable survival marker, although some lineages such as LGG and UVM show a favorable association.

UCS, ACC, and LGG are the cancer types where MAPK8IP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	III,IV	0.257	0.805	<.001	116	view →
ACC	DFS	Quartile	II,III,IV	0.149	0.721	<.001	62	view →
LGG	DFS	Median	All	0.508	0.315	<.001	52	view →
UVM	OS	Median	All	0.725	0.461	.008	44	view →
PRAD	OS	Median	All	0.779	0.939	.002	28	view →
BLCA	DFS	Median	All	0.239	0.468	.012	27	view →
PAAD	DFS	Quartile	All	0.601	0.225	.002	26	view →
COAD	DFS	Median	IV	0.324	0.616	<.001	18	view →
SCLC	OS	Tertile	All	0.830	0.583	.008	16	view →
LUAD	OS	Median	III,IV	0.741	0.573	.011	16	view →
HNSC	OS	Quartile	All	0.826	0.693	.009	16	view →
THYM	OS	Median	II,III,IV	0.889	1.000	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MAPK8IP2–UCS (OS)

Open the UCS breakdown →