MAPK8IP2

Across TCGA cell cohorts, MAPK8IP2 mutation is significantly associated with the RNA expression of many other genes, with 326 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK8IP2-associated genes across cancer lineages are KRTAP5-6, ZBED3, and PROP1. Each is linked with MAPK8IP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK8IP2-to-partner and partner-to-MAPK8IP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-6 grouped by MAPK8IP2-low versus MAPK8IP2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8IP2→partner) and Y-score (partner→MAPK8IP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRTAP5-6 →	+0.088	+4.022	.009	.001	3	2
LARGE_INTESTINE	ZBED3 →	+0.878	+2.502	.001	.005	3	2
LARGE_INTESTINE	PROP1 →	+0.012	+2.276	.008	.001	3	2
BLOOD_Lymphoma	SULT6B1 →	+0.023	+3.714	.005	.006	3	1
BLOOD_Lymphoma	ASB15 →	+0.882	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	SPZ1 →	+0.091	+3.714	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 326 associations by consensus.

KRTAP5-6 by MAPK8IP2 expression — OVARY

Explore this box plot interactively →