MAPK6

Across TCGA patient cohorts, MAPK6 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,818 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MAPK6-associated proteins across cancer lineages are MAPK6_S189, AKAP13_S983, and USP8. Each is linked with MAPK6 in more than 6 cancer types. Because this analysis shows association rather than direction, both MAPK6-to-partner and partner-to-MAPK6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAPK6 versus MAPK6_S189 in BRCA, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK6→partner) and Y-score (partner→MAPK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAPK6_S189 →	+0.919	+0.852	<.001	<.001	3	7
PDAC	AKAP13_S983 →	+0.675	+0.375	.001	<.001	3	6
LUAD	USP8 →	+0.173	+0.578	.004	<.001	3	5
HNSC	SEMA4B →	+0.587	+0.947	<.001	<.001	3	5
HNSC	KIAA1671_S1488 →	+0.682	+0.834	<.001	<.001	3	5
UCEC	VAV1 →	-0.635	-0.595	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,818 associations by consensus.

MAPK6 vs MAPK6_S189 — BRCA

Explore this scatter interactively →