MAPK6

Across TCGA patient cohorts, MAPK6 mutation is significantly associated with the RNA expression of many other genes, with 3,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK6-associated genes across cancer lineages are RNA5SP412, RN7SL134P, and RNA5SP418. Each is linked with MAPK6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPK6-to-partner and partner-to-MAPK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by MAPK6-low versus MAPK6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK6→partner) and Y-score (partner→MAPK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.429	+1.967	.001	.001	3	3
SKCM	RN7SL134P →	+0.151	+3.949	<.001	<.001	3	3
UCEC	RNA5SP418 →	+0.661	+1.863	<.001	.002	3	3
UCEC	RNA5SP413 →	+0.925	+1.736	<.001	.002	3	3
UCEC	RNA5SP415 →	+0.461	+1.974	<.001	.003	3	3
BRCA	RN7SKP117 →	+0.170	+5.580	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

RNA5SP412 by MAPK6 expression — UCEC

Explore this box plot interactively →