MAPK6

Across TCGA patient cohorts, MAPK6 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK6-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and eEF2. Each is linked with MAPK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK6-to-partner and partner-to-MAPK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MAPK6-low versus MAPK6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK6→partner) and Y-score (partner→MAPK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.580	+3.169	.007	.019	3	2
UCEC	14-3-3_beta →	-0.092	-2.558	.016	.010	3	1
UCEC	eEF2 →	+0.329	+1.678	.016	.023	3	1
UCEC	A-Raf_pS299 →	-0.093	-2.807	.042	.003	3	1
UCEC	ERK2 →	+0.165	+2.000	.025	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.152	-1.874	.018	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Cyclin-B1 by MAPK6 expression — UCEC

Explore this box plot interactively →