MAPK6

Across TCGA cell cohorts, MAPK6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,620 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MAPK6-associated GO terms across cancer lineages are Circadian sleep/wake cycle, Ubiquitin-dependent protein catabolic process via the N-end rule pathway, and Intracellular magnesium ion homeostasis. Each is linked with MAPK6 in more than 13 cancer types. Because this analysis shows association rather than direction, both MAPK6-to-partner and partner-to-MAPK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Circadian sleep/wake cycle grouped by MAPK6-low versus MAPK6-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK6→partner) and Y-score (partner→MAPK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Circadian sleep/wake cycle →	+0.215	+1.082	<.001	<.001	3	14
BLOOD_Lymphoma	Ubiquitin-dependent protein catabolic process via the N-end rule pathway →	+0.077	+1.216	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Intracellular magnesium ion homeostasis →	+0.100	+1.023	<.001	.001	2	12
OVARY	Transcription elongation by RNA polymerase II →	+0.081	+0.915	<.001	<.001	3	11
BONE	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.162	+0.807	<.001	<.001	3	10
BREAST	Phosphatidylinositol biosynthetic process →	+0.053	+0.798	.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,620 associations by consensus.

Circadian sleep/wake cycle by MAPK6 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →