MAPK4

Across TCGA patient cohorts, MAPK4 mutation is significantly associated with the RNA expression of many other genes, with 4,374 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK4-associated genes across cancer lineages are RN7SL478P, NIPAL2, and PSMD9. Each is linked with MAPK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPK4-to-partner and partner-to-MAPK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL478P grouped by MAPK4-low versus MAPK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK4→partner) and Y-score (partner→MAPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL478P →	+0.125	+1.410	.007	.004	3	3
SKCM	NIPAL2 →	-0.597	-2.127	.002	<.001	3	3
UCEC	PSMD9 →	+0.311	+1.732	.001	.002	3	3
UCEC	MPV17L →	-0.719	-3.392	<.001	<.001	3	3
SKCM	RFC4 →	+0.360	+1.736	.007	.006	3	3
HNSC	RNU4-84P →	+0.255	+4.924	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,374 associations by consensus.

RN7SL478P by MAPK4 expression — UCEC

Explore this box plot interactively →