MAP9

Across TCGA patient cohorts, MAP9 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP9-associated genes across cancer lineages are JNK_pT183_Y185, MIG-6, and RAD51. Each is linked with MAP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP9-to-partner and partner-to-MAP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MAP9-low versus MAP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP9→partner) and Y-score (partner→MAP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.146	-2.087	.007	.005	3	2
UCEC	MIG-6 →	+0.068	+3.321	.034	.009	3	2
UCEC	RAD51 →	+0.111	+2.000	.014	.029	3	2
UCEC	TIGAR →	+0.106	+1.248	.031	.023	3	2
UCEC	CD20 →	+0.098	+1.605	.021	.020	3	2
UCEC	4E-BP1 →	+0.268	+1.730	.002	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

JNK_pT183_Y185 by MAP9 expression — UCEC

Explore this box plot interactively →