MAP7D3

Across TCGA patient cohorts, MAP7D3 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP7D3-associated genes across cancer lineages are MSH2, ATM, and c-Jun_pS73. Each is linked with MAP7D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP7D3-to-partner and partner-to-MAP7D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by MAP7D3-low versus MAP7D3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP7D3→partner) and Y-score (partner→MAP7D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.157	-1.739	.018	.012	3	2
UCEC	ATM →	-0.340	-1.401	.009	.040	3	2
UCEC	c-Jun_pS73 →	-0.129	-2.253	.004	<.001	3	2
UCEC	EGFR_pY1068 →	-0.211	-1.736	.003	<.001	3	1
UCEC	HER2_pY1248 →	-0.161	-1.536	.035	.002	3	1
UCEC	JNK2 →	+0.143	+1.536	.012	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MSH2 by MAP7D3 expression — UCEC

Explore this box plot interactively →