MAP7D3

Across TCGA pan-cancer cohorts, MAP7D3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MAP7D3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAP7D3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAP7D3 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where MAP7D3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP7D3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.881	<.001	12	view →
KIRP	Female	All	+1.762	<.001	11	view →
KIRC	Female	All	+1.238	<.001	11	view →
THCA	All	IV	−1.472	<.001	10	view →
UCEC	All	All	−2.141	<.001	6	view →
BRCA	All	III,IV	−1.580	<.001	6	view →
BLCA	Male	IV	−1.612	.016	5	view →
LUAD	All	All	−0.445	<.001	5	view →
KICH	Female	All	−1.220	<.001	3	view →
CHOL	Female	All	+0.713	.020	2	view →
PRAD	All	All	−0.455	<.001	2	view →
LUSC	Male	All	+0.261	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MAP7D3–HNSC

Open the HNSC breakdown →