MAP6

Across TCGA cell cohorts, MAP6 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible MAP6-associated genes across cancer lineages are MMD2, MOGAT1, and FRMPD4. Each is linked with MAP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP6-to-partner and partner-to-MAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMD2 grouped by MAP6-low versus MAP6-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP6→partner) and Y-score (partner→MAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	2
BLOOD_Leukemia	MOGAT1 →	+0.023	+4.037	.008	.004	3	1
BLOOD_Leukemia	FRMPD4 →	+0.618	+4.037	<.001	.004	3	1
BLOOD_Leukemia	NCBP2L →	+0.021	+4.234	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.226	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	GPHB5 →	+0.053	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MMD2 by MAP6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →