MAP6

Across TCGA pan-cancer cohorts, MAP6 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MAP6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAP6 RNA is repressed in tumor relative to normal tissue. In most cancer types MAP6 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where MAP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.209	<.001	12	view →
KICH	Male	IV	−2.806	<.001	11	view →
KIRP	Male	II,III,IV	−2.234	<.001	9	view →
THCA	Male	III,IV	−1.654	<.001	9	view →
LUAD	Female	III,IV	−1.617	<.001	9	view →
UCEC	All	All	−2.176	<.001	8	view →
LUSC	Female	II,III,IV	−2.000	<.001	8	view →
COAD	Male	II,III,IV	−1.119	<.001	8	view →
STAD	All	All	−1.215	<.001	7	view →
BRCA	All	II,III,IV	−0.731	<.001	6	view →
READ	All	All	−1.712	<.001	5	view →
LIHC	All	All	+0.378	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MAP6–KIRC

Open the KIRC breakdown →