MAP4K5

Across TCGA cell cohorts, MAP4K5 mutation is significantly associated with the RNA expression of many other genes, with 247 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP4K5-associated genes across cancer lineages are OR5B2, TAS2R9, and LRIT1. Each is linked with MAP4K5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP4K5-to-partner and partner-to-MAP4K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5B2 grouped by MAP4K5-low versus MAP4K5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K5→partner) and Y-score (partner→MAP4K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR5B2 →	+0.033	+4.169	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	TAS2R9 →	+0.049	+4.870	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	LRIT1 →	+0.042	+4.870	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	VWC2L →	+0.018	+4.209	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A1 →	+0.047	+5.321	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	OR52N5 →	+0.020	+4.357	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 247 associations by consensus.

OR5B2 by MAP4K5 expression — CNS

Explore this box plot interactively →