MAP4K4

Across TCGA pan-cancer cohorts, MAP4K4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MAP4K4 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MAP4K4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP4K4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

PDAC, HNSC, and OV are the cancer types where MAP4K4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.670	0.915	<.001	63	view →
HNSC	OS	Quartile	II,III,IV	0.837	0.571	.020	9	view →
OV	DFS	Median	All	0.975	0.603	.033	8	view →
LSCC	OS	Median	II,III,IV	0.938	0.753	.021	2	view →
UCEC	DFS	Quartile	All	1.000	0.892	.036	2	view →
LUAD	OS	Quartile	III,IV	0.382	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MAP4K4–PDAC (DFS)

Open the PDAC breakdown →