MAP4K4

Across TCGA pan-cancer cohorts, MAP4K4 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MAP4K4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAP4K4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAP4K4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where MAP4K4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP4K4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.596	<.001	12	view →
KIRP	Female	All	+1.474	<.001	11	view →
KIRC	Female	All	+1.474	<.001	11	view →
COAD	All	III,IV	+0.976	<.001	11	view →
LIHC	Female	II,III,IV	+1.545	<.001	9	view →
STAD	Male	II,III,IV	+1.374	<.001	9	view →
THCA	Female	III,IV	+0.874	<.001	8	view →
LUSC	Male	II,III,IV	+0.942	<.001	7	view →
UCEC	All	II,III,IV	+0.975	.002	6	view →
BLCA	All	All	+0.577	.008	6	view →
CHOL	Male	All	+2.403	<.001	5	view →
LUAD	Male	II,III,IV	+0.945	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MAP4K4–HNSC

Open the HNSC breakdown →