MAP4K4

Across TCGA patient cohorts, MAP4K4 mutation is significantly associated with the RNA expression of many other genes, with 4,778 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP4K4-associated genes across cancer lineages are GOT1, COQ2, and WSB2. Each is linked with MAP4K4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP4K4-to-partner and partner-to-MAP4K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by MAP4K4-low versus MAP4K4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K4→partner) and Y-score (partner→MAP4K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GOT1 →	+0.287	+1.742	.005	<.001	3	4
UCEC	COQ2 →	+0.292	+1.869	.009	.004	3	3
UCEC	WSB2 →	+0.408	+2.385	<.001	<.001	3	3
COAD	TIMM22 →	+0.416	+2.515	<.001	.001	3	3
UCEC	PIGH →	+0.315	+1.958	.004	.002	3	3
UCEC	MYO5C →	+0.452	+1.505	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,778 associations by consensus.

GOT1 by MAP4K4 expression — UCEC

Explore this box plot interactively →