MAP4K4

Across TCGA patient cohorts, MAP4K4 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP4K4-associated genes across cancer lineages are Cyclin-E2, Caspase-7-cleavedD198, and eEF2. Each is linked with MAP4K4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAP4K4-to-partner and partner-to-MAP4K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by MAP4K4-low versus MAP4K4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K4→partner) and Y-score (partner→MAP4K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-E2 →	+0.210	+2.334	.008	.018	3	4
COAD	Caspase-7-cleavedD198 →	+1.498	+2.815	<.001	.001	3	4
COAD	eEF2 →	+0.362	+2.321	.001	.033	3	3
UCEC	FoxM1 →	+0.154	+1.530	.048	.004	3	3
COAD	GAPDH →	+0.536	+2.123	.007	.010	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.423	-1.662	.001	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Cyclin-E2 by MAP4K4 expression — SKCM

Explore this box plot interactively →