MAP4K4

Across TCGA cell cohorts, MAP4K4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,929 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP4K4-associated GO terms across cancer lineages are Regulation of cell-substrate junction organization, Protein depolymerization, and Regulation of cell-matrix adhesion. Each is linked with MAP4K4 in more than 15 cancer types. Because this analysis shows association rather than direction, both MAP4K4-to-partner and partner-to-MAP4K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction organization grouped by MAP4K4-low versus MAP4K4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K4→partner) and Y-score (partner→MAP4K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of cell-substrate junction organization →	+0.119	+1.783	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Protein depolymerization →	+0.141	+1.178	<.001	<.001	3	16
OESOPHAGUS	Regulation of cell-matrix adhesion →	+0.117	+1.273	<.001	.004	3	15
STOMACH	Regulation of cell-substrate junction assembly →	+0.101	+0.985	<.001	<.001	3	15
STOMACH	Regulation of focal adhesion assembly →	+0.101	+0.985	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Response to dehydroepiandrosterone →	+0.232	+1.328	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,929 associations by consensus.

Regulation of cell-substrate junction organization by MAP4K4 expression — STOMACH

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