MAP4K4

Across TCGA cell cohorts, MAP4K4 mutation is significantly associated with the RNA expression of many other genes, with 1,108 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP4K4-associated genes across cancer lineages are GSG1L2, NDC1, and IL36A. Each is linked with MAP4K4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP4K4-to-partner and partner-to-MAP4K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by MAP4K4-low versus MAP4K4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K4→partner) and Y-score (partner→MAP4K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSG1L2 →	+0.028	+3.969	<.001	.009	3	2
LARGE_INTESTINE	NDC1 →	+0.729	+3.628	<.001	<.001	3	2
LUNG_SCLC	IL36A →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	OR7G3 →	+0.063	+5.643	<.001	.002	3	1
LUNG_SCLC	DEFB132 →	+0.012	+5.029	<.001	.006	3	1
LUNG_SCLC	FAM25A →	+0.186	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,108 associations by consensus.

GSG1L2 by MAP4K4 expression — BLOOD_Leukemia

Explore this box plot interactively →