MAP4K3

Across TCGA patient cohorts, MAP4K3 mutation is significantly associated with the RNA expression of many other genes, with 3,884 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP4K3-associated genes across cancer lineages are BRPF1, FANCC, and WASF2. Each is linked with MAP4K3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP4K3-to-partner and partner-to-MAP4K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRPF1 grouped by MAP4K3-low versus MAP4K3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K3→partner) and Y-score (partner→MAP4K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BRPF1 →	+0.471	+2.951	<.001	<.001	3	3
UCEC	FANCC →	+0.436	+4.202	<.001	<.001	3	3
SKCM	WASF2 →	+0.571	+2.631	<.001	.005	3	3
UCEC	ORC5 →	+0.437	+2.445	<.001	<.001	3	3
UCEC	LETM1 →	+0.439	+2.997	<.001	<.001	3	3
UCEC	C15orf40 →	+0.187	+1.959	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,884 associations by consensus.

BRPF1 by MAP4K3 expression — SKCM

Explore this box plot interactively →