MAP4K3

Across TCGA pan-cancer cohorts, MAP4K3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAP4K3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAP4K3 RNA is repressed in tumor relative to normal tissue. In most cancer types MAP4K3 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where MAP4K3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP4K3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.805	<.001	11	view →
HNSC	All	III,IV	+0.726	<.001	11	view →
THCA	All	II,III,IV	−0.763	<.001	10	view →
LIHC	Female	II,III,IV	+1.124	<.001	8	view →
BLCA	All	IV	+0.834	<.001	8	view →
CHOL	Female	All	+3.116	<.001	5	view →
KICH	Female	All	−1.225	<.001	5	view →
LUAD	Male	All	+0.582	<.001	5	view →
KIRP	Male	All	−0.764	<.001	4	view →
COAD	Male	All	+0.513	<.001	4	view →
PAAD	All	All	+0.532	.034	2	view →
BRCA	All	II,III,IV	+0.195	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAP4K3–KIRC

Open the KIRC breakdown →