MAP4K3

Across TCGA patient cohorts, MAP4K3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP4K3-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and 14-3-3_beta. Each is linked with MAP4K3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP4K3-to-partner and partner-to-MAP4K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAP4K3-low versus MAP4K3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K3→partner) and Y-score (partner→MAP4K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.542	+1.697	.005	.012	3	3
UCEC	C-Raf →	+0.166	+1.584	<.001	.017	3	3
UCEC	14-3-3_beta →	-0.100	-2.673	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.231	-1.652	.005	.006	3	2
UCEC	eIF4E →	+0.216	+2.263	.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.465	+2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by MAP4K3 expression — UCEC

Explore this box plot interactively →