MAP4K3

Across TCGA cell cohorts, MAP4K3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,008 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP4K3-associated GO terms across cancer lineages are Protein localization to vacuole, Stress granule assembly, and Protein targeting to vacuole. Each is linked with MAP4K3 in more than 14 cancer types. Because this analysis shows association rather than direction, both MAP4K3-to-partner and partner-to-MAP4K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to vacuole grouped by MAP4K3-low versus MAP4K3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K3→partner) and Y-score (partner→MAP4K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Protein localization to vacuole →	+0.074	+0.957	.004	<.001	3	15
LUNG_NSCLC_LUSC	Stress granule assembly →	+0.129	+0.804	<.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Protein targeting to vacuole →	+0.085	+0.854	<.001	.003	3	14
BREAST	Golgi vesicle transport →	+0.076	+0.940	<.001	<.001	3	14
URINARY_TRACT	Process utilizing autophagic mechanism →	+0.049	+0.847	<.001	.005	3	13
URINARY_TRACT	Autophagy →	+0.049	+0.847	<.001	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,008 associations by consensus.

Protein localization to vacuole by MAP4K3 expression — STOMACH

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