MAP4K3

Across TCGA cell cohorts, MAP4K3 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP4K3-associated genes across cancer lineages are OR1M1, SERPINA12, and OPRPN. Each is linked with MAP4K3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP4K3-to-partner and partner-to-MAP4K3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1M1 grouped by MAP4K3-low versus MAP4K3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K3→partner) and Y-score (partner→MAP4K3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR1M1 →	+0.034	+4.217	.003	.005	3	2
PANCREAS	SERPINA12 →	+0.016	+5.614	<.001	.002	3	1
PANCREAS	OPRPN →	+0.029	+5.000	<.001	.006	3	1
PANCREAS	USP17L3 →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	ZIM2 →	+0.027	+5.000	.006	.006	3	1
URINARY_TRACT	SIGLEC5 →	+0.957	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

OR1M1 by MAP4K3 expression — URINARY_TRACT

Explore this box plot interactively →