MAP4K2

Across TCGA patient cohorts, MAP4K2 mutation is significantly associated with the RNA expression of many other genes, with 3,633 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP4K2-associated genes across cancer lineages are RNA5SP477, RNU6-933P, and MIR3908. Each is linked with MAP4K2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP4K2-to-partner and partner-to-MAP4K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP477 grouped by MAP4K2-low versus MAP4K2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K2→partner) and Y-score (partner→MAP4K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP477 →	+0.972	+3.463	<.001	.008	3	3
COAD	RNU6-933P →	+0.408	+4.314	<.001	<.001	3	3
COAD	MIR3908 →	+0.226	+5.412	<.001	.001	3	3
SKCM	SMC5-AS1 →	+0.347	+3.516	.005	.002	3	2
LIHC	SFPQP1 →	+0.028	+4.423	<.001	.007	3	2
UCEC	BOLA2P2 →	+0.285	+3.732	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,633 associations by consensus.

RNA5SP477 by MAP4K2 expression — COAD

Explore this box plot interactively →