MAP4K2

Across TCGA cell cohorts, MAP4K2 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAP4K2-associated genes across cancer lineages are VIPR2, PHOX2B, and FAM149A. Each is linked with MAP4K2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP4K2-to-partner and partner-to-MAP4K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VIPR2 grouped by MAP4K2-low versus MAP4K2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K2→partner) and Y-score (partner→MAP4K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VIPR2 →	+1.619	+3.507	<.001	.003	3	1
BLOOD_Leukemia	PHOX2B →	+0.017	+3.687	<.001	<.001	3	1
BLOOD_Leukemia	FAM149A →	+0.993	+3.309	<.001	.006	3	1
BLOOD_Leukemia	RBPJL →	+0.301	+3.418	<.001	.007	3	1
BLOOD_Leukemia	BCL11B →	+2.623	+3.351	<.001	.005	3	1
BLOOD_Leukemia	BTBD16 →	+0.074	+2.696	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

VIPR2 by MAP4K2 expression — BLOOD_Leukemia

Explore this box plot interactively →