MAP4

Across TCGA patient cohorts, MAP4 mutation is significantly associated with the RNA expression of many other genes, with 2,513 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP4-associated genes across cancer lineages are LDHA, FAM153DP, and RNU7-167P. Each is linked with MAP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP4-to-partner and partner-to-MAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LDHA grouped by MAP4-low versus MAP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4→partner) and Y-score (partner→MAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LDHA →	+0.463	+1.616	<.001	<.001	3	3
LIHC	FAM153DP →	+0.120	+4.822	<.001	.003	3	2
BLCA	RNU7-167P →	+0.173	+3.562	<.001	.002	3	2
BLCA	RN7SL310P →	+0.116	+2.681	<.001	.007	3	2
UCEC	CEBPA-DT →	-0.438	-1.545	.003	.004	3	2
LIHC	MAGED4 →	+0.024	+4.451	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,513 associations by consensus.

LDHA by MAP4 expression — UCEC

Explore this box plot interactively →