MAP4

Across TCGA cell cohorts, MAP4 mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP4-associated genes across cancer lineages are MAGEB3, CYP2A13, and FAM149A. Each is linked with MAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP4-to-partner and partner-to-MAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB3 grouped by MAP4-low versus MAP4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4→partner) and Y-score (partner→MAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MAGEB3 →	+0.057	+4.222	<.001	.007	3	2
CNS	CYP2A13 →	+0.021	+3.459	.001	.006	3	2
BLOOD_Leukemia	FAM149A →	+0.989	+3.309	<.001	.006	3	2
BLOOD_Myeloma	OR2V1 →	+0.030	+4.700	<.001	<.001	3	1
SOFT_TISSUE	DMRTC2 →	+0.019	+4.369	<.001	.008	3	1
LUNG_NSCLC_LUSC	SMR3A →	+0.063	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

MAGEB3 by MAP4 expression — SOFT_TISSUE

Explore this box plot interactively →