MAP3K8

Across TCGA pan-cancer cohorts, MAP3K8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MAP3K8 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MAP3K8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MAP3K8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where MAP3K8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.942	0.561	.001	30	view →
CCRCC	OS	Median	III,IV	0.104	0.989	.010	21	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.465	.036	8	view →
LSCC	DFS	Quartile	II,III,IV	0.515	0.877	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MAP3K8–PDAC (DFS)

Open the PDAC breakdown →