MAP3K7CL

Across TCGA patient cohorts, MAP3K7CL mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K7CL-associated genes across cancer lineages are MEK1, Notch1, and p62 Lck ligand. Each is linked with MAP3K7CL in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K7CL-to-partner and partner-to-MAP3K7CL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MAP3K7CL-low versus MAP3K7CL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K7CL→partner) and Y-score (partner→MAP3K7CL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.430	+3.700	.011	.001	3	1
UCEC	Notch1 →	+0.182	+3.179	.005	.010	3	1
UCEC	p62 Lck ligand →	+0.474	+2.999	.001	.035	3	1
UCEC	PDCD4 →	-0.636	-3.700	.003	.001	2	2
UCEC	VHL →	-0.923	-2.321	.003	.034	3	1
UCEC	ASNS →	+0.432	+3.000	.010	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by MAP3K7CL expression — UCEC

Explore this box plot interactively →