MAP3K7CL

Across TCGA pan-cancer cohorts, MAP3K7CL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAP3K7CL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAP3K7CL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAP3K7CL is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

KIRC, LIHC, and COAD are the cancer types where MAP3K7CL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K7CL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.095	<.001	11	view →
LIHC	Male	All	+0.864	<.001	8	view →
COAD	All	All	+0.352	<.001	8	view →
LUSC	Male	III,IV	−1.487	<.001	7	view →
UCEC	All	III,IV	−1.742	<.001	6	view →
STAD	All	All	+0.431	<.001	6	view →
LUAD	All	All	−0.367	<.001	6	view →
BRCA	All	All	+0.153	.016	4	view →
CHOL	All	All	+1.144	<.001	3	view →
HNSC	Female	III,IV	+1.074	.001	3	view →
ESCA	All	All	+0.740	.019	1	view →
KICH	All	All	−0.547	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAP3K7CL–KIRC

Open the KIRC breakdown →