MAP3K5-AS1

Across TCGA pan-cancer cohorts, MAP3K5-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MAP3K5-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MAP3K5-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MAP3K5-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUSC show a favorable association.

HNSC, KIRC, and LUAD are the cancer types where MAP3K5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.757	0.621	<.001	139	view →
KIRC	OS	Median	All	0.578	0.733	<.001	64	view →
LUAD	DFS	Median	All	0.546	0.748	<.001	51	view →
LUSC	OS	Tertile	III,IV	0.689	0.414	.004	39	view →
SKCM	OS	Median	IV	0.894	0.292	<.001	30	view →
GBM	OS	Tertile	All	0.307	0.452	.014	21	view →
CHOL	OS	Tertile	II,III,IV	0.080	0.740	.026	18	view →
LGG	OS	Median	All	0.978	0.834	<.001	15	view →
KIRP	OS	Median	All	0.514	0.883	.015	10	view →
TGCT	DFS	Median	All	0.909	0.753	.005	10	view →
DLBC	DFS	Median	II,III,IV	0.653	0.956	.009	9	view →
ACC	OS	Tertile	IV	0.405	0.886	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MAP3K5-AS1–HNSC (DFS)

Open the HNSC breakdown →