MAP3K5-AS1

Across TCGA pan-cancer cohorts, MAP3K5-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MAP3K5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MAP3K5-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MAP3K5-AS1 is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

HNSC, THCA, and STAD are the cancer types where MAP3K5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.485	<.001	8	view →
THCA	Male	All	+0.627	<.001	7	view →
STAD	All	II,III,IV	+0.496	.002	6	view →
BRCA	All	III,IV	−0.354	<.001	6	view →
KIRC	Male	All	+0.195	<.001	6	view →
UCEC	All	All	−0.407	.011	4	view →
BLCA	Male	All	+0.698	.010	2	view →
KIRP	All	All	+0.271	.046	1	view →
LUSC	All	All	+0.195	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

MAP3K5-AS1–HNSC

Open the HNSC breakdown →