MAP3K4

Across TCGA patient cohorts, MAP3K4 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP3K4-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and FASN. Each is linked with MAP3K4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAP3K4-to-partner and partner-to-MAP3K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MAP3K4-low versus MAP3K4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K4→partner) and Y-score (partner→MAP3K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.463	+1.925	<.001	.004	3	3
COAD	Caspase-7-cleavedD198 →	+0.892	+2.338	.001	.017	3	3
UCEC	FASN →	+0.251	+1.321	.030	.027	3	3
UCEC	TFRC →	+0.447	+2.807	.004	.002	3	3
UCEC	ATM →	-0.516	-2.489	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.830	+2.099	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

ASNS by MAP3K4 expression — UCEC

Explore this box plot interactively →