MAP3K4

Across TCGA pan-cancer cohorts, MAP3K4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAP3K4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MAP3K4 RNA is repressed in tumor relative to normal tissue. In most cancer types MAP3K4 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, COAD, and LIHC are the cancer types where MAP3K4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAP3K4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.887	<.001	9	view →
COAD	All	All	+0.286	<.001	8	view →
LIHC	Female	II,III,IV	+0.740	<.001	7	view →
LUAD	Female	II,III,IV	−0.633	.001	7	view →
KICH	Female	All	−0.741	<.001	6	view →
BRCA	Female	All	−0.313	<.001	6	view →
CHOL	All	All	+1.578	<.001	5	view →
LUSC	All	All	+0.460	<.001	5	view →
HNSC	All	All	+0.348	.002	5	view →
PAAD	Male	All	−0.410	.010	4	view →
READ	All	III,IV	+1.110	.015	2	view →
UCEC	All	All	−0.554	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAP3K4–THCA

Open the THCA breakdown →