MAP3K4

Across TCGA cell cohorts, MAP3K4 mutation is significantly associated with the RNA expression of many other genes, with 2,418 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K4-associated genes across cancer lineages are TEX50, GPR119, and HPS4. Each is linked with MAP3K4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP3K4-to-partner and partner-to-MAP3K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX50 grouped by MAP3K4-low versus MAP3K4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K4→partner) and Y-score (partner→MAP3K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TEX50 →	+0.030	+4.643	<.001	.004	3	2
STOMACH	GPR119 →	+0.067	+3.432	.003	.008	3	2
LARGE_INTESTINE	HPS4 →	+0.445	+2.036	.008	.002	3	2
LARGE_INTESTINE	CCDC134 →	+0.784	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	HMGXB4 →	+0.630	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	TNRC6B →	+0.818	+2.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,418 associations by consensus.

TEX50 by MAP3K4 expression — LUNG_SCLC

Explore this box plot interactively →