MAP3K4

Across TCGA cell cohorts, MAP3K4 mutation is significantly associated with the mutation status of many other genes, with 6,817 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP3K4-associated genes across cancer lineages are FREM2, TRERF1, and ZNF609. Each is linked with MAP3K4 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAP3K4-to-partner and partner-to-MAP3K4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FREM2 grouped by MAP3K4-low versus MAP3K4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP3K4→partner) and Y-score (partner→MAP3K4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FREM2 →	+3.025	+3.139	.009	.009	1	5
BLOOD_Lymphoma	TRERF1 →	+3.337	+2.969	.009	.009	1	5
BLOOD_Lymphoma	ZNF609 →	+2.752	+2.847	.005	.005	1	5
LUNG_NSCLC_LUAD	CDH24 →	+4.584	+4.584	<.001	<.001	1	5
BONE	SBF1 →	+3.708	+3.240	.006	.006	1	4
BLOOD_Lymphoma	GRWD1 →	+3.922	+3.247	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,817 associations by consensus.

FREM2 by MAP3K4 expression — CNS

Explore this box plot interactively →