MAP3K4-AS1

Across TCGA pan-cancer cohorts, MAP3K4-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MAP3K4-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MAP3K4-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAP3K4-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and ACC show a favorable association.

KIRP, MESO, and KICH are the cancer types where MAP3K4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.733	0.971	<.001	127	view →
MESO	OS	Tertile	All	0.266	0.564	<.001	75	view →
KICH	DFS	Quartile	II,III,IV	0.375	1.000	.009	42	view →
LIHC	OS	Tertile	II,III,IV	0.236	0.594	.001	40	view →
LUSC	DFS	Median	III,IV	0.184	0.501	<.001	36	view →
HNSC	OS	Tertile	III,IV	0.703	0.825	.003	32	view →
UVM	OS	Quartile	All	0.589	0.950	.012	30	view →
BLCA	OS	Quartile	II,III,IV	0.299	0.544	.004	29	view →
CESC	DFS	Median	II,III,IV	0.602	0.796	.011	22	view →
ESCA	OS	Median	All	1.000	0.670	.026	18	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	15	view →
ACC	DFS	Tertile	III,IV	0.531	0.078	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MAP3K4-AS1–KIRP (DFS)

Open the KIRP breakdown →